CellRegMap

The Cellular Regulatory Map (CellRegMap) is a linear mixed model approach to test for and characterize context-specific eQTL variants across several cell contexts and states. CellRegMap leverages single cell RNA sequencing (scRNA-seq) data, and does not require discretization of cells into cell groups. CellRegMap builds on the previously proposed StructLMM but importantly can account for repeated observations for the same samples, e.g., multiple cells for the same donor, and for population stratification and relatedness.

For more details on the CellRegMap model and its applications to both real and simulated data, see our paper.